Paul Gissen Selected Research

Terminal Care (Care, Terminal)

1/2021

Guidelines on the diagnosis, clinical assessments, treatment and management for CLN2 disease patients.

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Paul Gissen Research Topics

Disease

8	Arthrogryposis renal dysfunction cholestasis syndrome 01/2016 - 04/2004
7	Liver Diseases (Liver Disease) 02/2024 - 05/2012
7	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 02/2024 - 10/2015
7	Epilepsy (Aura) 12/2023 - 08/2011
6	Ornithine Carbamoyltransferase Deficiency Disease 12/2023 - 10/2015
6	Parkinson Disease (Parkinson's Disease) 01/2022 - 07/2006
5	Argininosuccinic Aciduria 02/2024 - 01/2017
5	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 01/2024 - 01/2018
5	AIDS-Related Complex (ARC) 04/2010 - 12/2005
4	Metabolic Diseases (Metabolic Disease) 02/2024 - 08/2011
4	Disease Progression 01/2023 - 01/2014
4	Seizures (Absence Seizure) 01/2021 - 10/2010
3	Arthrogryposis 08/2023 - 04/2004
3	Mucopolysaccharidoses 06/2023 - 12/2015
3	Tyrosinemias (Tyrosinemia) 01/2022 - 10/2015
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 07/2006
3	Dystonia (Limb Dystonia) 02/2017 - 01/2016
3	Brain Diseases (Brain Disorder) 09/2015 - 10/2010
3	Cholestasis 01/2013 - 04/2004
2	Phenylketonurias (Phenylketonuria) 01/2024 - 01/2022
2	Movement Disorders (Movement Disorder) 12/2023 - 06/2009
2	Lysosomal Storage Diseases (Lysosomal Storage Disease) 06/2023 - 01/2021
2	Mitochondrial Diseases (Mitochondrial Disease) 06/2021 - 01/2019
2	Infections 01/2018 - 01/2013
2	Atrophy 01/2017 - 11/2014
2	Pyridoxamine 5-Prime-Phosphate Oxidase Deficiency 01/2017 - 05/2014
2	Parkinsonian Disorders (Parkinsonism) 01/2016 - 08/2011
2	Infantile Spasms (West Syndrome) 05/2014 - 10/2010
2	Inborn Genetic Diseases (Disease, Hereditary) 09/2007 - 07/2006
1	Chronic Brain Damage 02/2024
1	Hypertension (High Blood Pressure) 02/2024
1	Maple Syrup Urine Disease 01/2024
1	Hepatolenticular Degeneration (Wilson's Disease) 01/2024
1	Hepatorenal form of glycogen storage disease 01/2024
1	Gaucher Disease (Gaucher's Disease) 06/2023
1	Fabry Disease (Fabry's Disease) 06/2023
1	Metachromatic Leukodystrophy (Sulfatide Lipidosis) 02/2023
1	Autism Spectrum Disorder 01/2023
1	Language Development Disorders (Semantic-Pragmatic Disorder) 01/2023
1	Hyperammonemia 12/2021
1	Pain (Aches) 12/2021
1	Hypersensitivity (Allergy) 01/2021
1	Fever (Fevers) 01/2021
1	Rare Diseases (Rare Disease) 01/2021
1	Synucleinopathies 10/2020
1	Body Weight (Weight, Body) 01/2020
1	Muscular Atrophy (Muscle Atrophy) 01/2020
1	Mucopolysaccharidosis I (Hurler Syndrome) 01/2020
1	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 01/2020

Drug/Important Bio-Agent (IBA)

13	Proteins (Proteins, Gene)FDA Link 01/2019 - 12/2005
7	Urea (Carbamide)FDA LinkGeneric 02/2024 - 01/2018
7	EnzymesIBA 02/2023 - 03/2010
5	Tripeptidyl-Peptidase 1IBA 01/2024 - 01/2018
5	Biomarkers (Surrogate Marker)IBA 06/2023 - 12/2015
4	cerliponase alfaIBA 01/2024 - 01/2018
3	CollagenIBA 08/2023 - 01/2016
3	LipidsIBA 06/2023 - 12/2005
3	Dopamine (Intropin)FDA LinkGeneric 01/2023 - 06/2009
3	AmmoniaIBA 12/2021 - 01/2017
3	SynucleinsIBA 10/2020 - 01/2017
2	Argininosuccinate LyaseIBA 02/2024 - 01/2018
2	acetylleucineIBA 02/2024 - 03/2022
2	Messenger RNA (mRNA)IBA 01/2024 - 02/2009
2	Ornithine Carbamoyltransferase (Ornithine Transcarbamylase)IBA 01/2023 - 10/2015
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2023 - 01/2018
2	Arginine (L-Arginine)FDA Link 01/2023 - 12/2021
2	alpha-SynucleinIBA 01/2022 - 03/2016
2	Phenylalanine (L-Phenylalanine)FDA Link 01/2022 - 12/2019
2	Tyrosine (L-Tyrosine)FDA Link 01/2022 - 12/2019
2	Lysine (L-Lysine)FDA Link 01/2020 - 02/2017
2	Histone MethyltransferasesIBA 02/2017 - 01/2017
2	Oxidoreductases (Dehydrogenase)IBA 01/2017 - 05/2014
2	Pyridoxine (Pyridoxin)FDA LinkGeneric 05/2014 - 10/2006
2	Member 11 Subfamily B ATP Binding Cassette TransporterIBA 06/2013 - 11/2010
2	Membrane Proteins (Integral Membrane Proteins)IBA 04/2013 - 10/2006
2	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA 01/2013 - 04/2004
2	Bile Acids and Salts (Bile Acids)IBA 01/2013 - 05/2012
2	Neurotransmitter Agents (Neurotransmitter)IBA 08/2011 - 03/2005
1	Lipid NanoparticlesIBA 01/2024
1	4-(3-fluoropropyl)glutamic acidIBA 01/2024
1	Glutathione (Reduced Glutathione)IBA 01/2024
1	CatecholaminesIBA 12/2023
1	dihexosylceramideIBA 06/2023
1	globotriaosylceramide (globotriosylceramide)IBA 06/2023
1	Cerebroside-Sulfatase (Arylsulfatase A)IBA 02/2023
1	SphingolipidsIBA 02/2023
1	NitrogenIBA 12/2021
1	AntibodiesIBA 01/2021
1	hydroxide ionIBA 01/2020
1	Antisense OligonucleotidesIBA 01/2020
1	Indicators and Reagents (Reagents)IBA 01/2020
1	glycosylated hydroxylysineIBA 01/2020
1	MyostatinIBA 01/2020

Therapy/Procedure

9	Therapeutics 01/2024 - 01/2014
4	Enzyme Replacement Therapy 01/2024 - 12/2010
4	Liver Transplantation 12/2023 - 10/2015
1	Investigational Therapies (Experimental Therapy) 01/2024
1	Protein-Restricted Diet (Diet, Protein Restricted) 12/2021
1	Terminal Care (Care, Terminal) 01/2021
1	Pain Management 01/2021